McGregor developed a modification of the Chamberlain line for when the opisthion could not be identified on plain radiographs. Chamberlain line is a line joining the back of hard palate with the opisthion on a lateral view of the craniocervical junction.
Connecting the posterior border of hard palate and opisthion.

Mcgregor line radiopaedia. It helps to recognize basilar invagination which is said to be present if the tip of the dens is 3 mm above this line. The tip of the odontoid process projects normally not more than 3 mm above this line. Connecting the posterior edge of the hard palate to the most caudal point of the occipital curve.

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